1) API name : Rosuvastatin

1-1) Original Brand : Crestor

1-2) Generic Brand : Rosulip, Zuvamor etc,.


2) Medical Uses of Rosuvastatin 

2-1) Effects on Cholesterol Level

It inhibits HMG-COA reductase, which is an enzyme related to the synthesis of Cholesterol in Body.

2-2) Mechanism



2-3) Effect on LDL (Low-density lipprotein)

(Maximum dose is 20mg per Day)

Dose

Decrease in LDL

5mg

30~40%

10mg

40~45%

15mg

46~50%

20mg

50~55%


3) Side Effects
3-1) Hepatotoxicity(Liver toxicity), reported by 2~3% of patients
>Generally accompanying Tiredness, loss of appetite, depression and jaundice
>Recommend to take periodical liver test

3-2) Muscle pain, reported by 10~15% of patients
>Rosuvastatin(Crestor) can affect to muscle cell and cause muscle pain.

4) Drug interactions
> Aluminum and Magnesium hydroxide antacids should not be taken within two hours of taking Rosuvastatin (May decrease blood concentration of Rosuvastatin by 50%)
> taking Rosuvastatin together with Immunosuppressive such as Cyclosporine or itraconazole may cause high risk of increasing liver toxicity